As I start connecting signals on the schematic, I look at which pins have dedicated functions.  The dedicated functions I need, I handle first.  This allows me to adjust the rest of the design around the required elements.  To make the schematic easier to read, I try to avoid crossing traces.

I went into the library editor and moved the pins of the ESP-12E around to make it easier to read the schematic.

I have connected the SPI pins from the ESP-12E to the level shifter chips.  I have also connected four GPIO pins to the level shifter chips.   I have placed the 3.3V power connections to each of the level shifter chips and the ESP-12E. I have also tied the 3.3V regulator to the 3.3V power bus. I connected GPIO0, GPIO2, GPIO4, GPIO5 to the direction pins of the level shifter chips.  I have also connected Vt to the level shifter chips. this voltage will come from the target to be programmed.

I have ordered 5 ESP-12E boards from Ebay.  I should receive them within 30 days.  Once I receive them, I will start doing a basic hello world project.